Restylane® Refyne is manufactured by one of the largest and most respected dermatology companies in the world, Galderma; which is owned by Nestle Skin Health. Refyne is a hyaluronic acid filler from the Restylane family of products. Refyne is used for the correction of deeper wrinkles of the face such as nasolabial folds (smile lines). Restylane® Refyne is designed with XpresHAn Technology™ to help soften laugh lines (nasolabial folds and marionette lines). This can help you restore a more natural look to your face while maintaining your facial expressions while maintaining your natural appearance.